Product ID:3-CYANOPYRIDINE, 150740
MSDS Date:01/07/1994
FSC:6810
NIIN:00N055995
MSDS Number: CDKZB

ICN BIOMEDICALS INC

1263 S CHILLICOTHE RD
AURORA, OH 44202
US

Emergency Phone: 800-424-9300(CHEMTREC)

Info Phone: 216-562-1500

Preparer: RL

Cage: IO030

ICN BIOMEDICALS INC

28050 CLEVELAND, OH 44128-0250 US

Telephone: 216-831-3000

Cage: IO030

NICOTINONITRILE; (3-CYANOPYRIDINE)

CAS: 100-54-9

RTECS: QT3030000

OSHA PEL N/K

ACGIH TLV: N/K

WHICH LATTER CAN BE RELSD BY ACTION OF

RTECS: 9999999ZZ

TISS, HUMAN INTESTINAL MICROFLORA APPEAR TO HAVE

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IN HUMAN POIS; THEREFORE AMYGDALIN MAY BE AS MUCH AS

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MAJOR INGRED OF LAETRILE & THIS ALLEGED ANTICANCER

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DRUG THAT MAY ALSO CAUSE POIS IN OVERDOSE IS POTENT

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IS CHEM RELATED TO FERRICYANIDE BUT UNLIKE LATTER IT

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RELS CYANIDE THOUGH ITS THERAPEUTIC MARGIN APPEARS

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SILVER & METAL POLISH, PHOTOGRAPHIC SOLNS &

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FROM CHEM STORES. CYANIDE EASILY ABSORBED BY ALL

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CYANIDE ARE TOX ONLY WHEN INGEST. DEATH MAY OCCUR

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CAN OCCUR W/IN MIN/HR DEPEND ON EXPOS ROUTE. INHAL

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NITROPRUSSIDE & APRICOT SEEDS HAVE CAUSED POIS.

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USUALLY HAVE LEVELS >1UG/ML. CLINICALLY, CYANIDE

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SHARE OF POPULATION IS GENETICALLY ABLE TO DISCERN

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& AFTER POIS, SYMPS OF SALIVATION, NAUS W/OUT

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CONVL, OPISTHOTONOS, PARALYSIS, COMA,CARD ARRHY &

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OCCUR. BRADYCARDIA COMMON BUT HEARTBEAT USUALLY

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CHARACT OF POIS. VOLAT CYANIDES RESEMBLE

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CAUSE DEATH THRU ASPHY. CYANOGEN PROBABLY AS TOX AS

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LOWER VOLAT. NON-VOLAT CYANIDE SALTS APPEAR NON-TOX

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OF HYDROCYANIC ACID. WORKERS EXPOSED DAILY TO

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PAPULAR & VESICULAR ERUPTIONS; POSS SECONDARY

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REPORTED TO CAUSE LOSS OF APPETITE, HDCH, WEAK,

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FRESH AIR,REST. IF UNCON IMMINENT CLEAR RESP

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LD50 LC50 Mixture:LD50: (ORAL, RAT) 1185 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:MOD TOX BY INGEST. POSS BY OTHER
ROUTES. MOD TO SEV ERYTH(REDNESS) & MOD EDEMA(RAISED SKIN). REMARKS
ON CYANIDE:DIRECTLY STIMULATES CHEMORECEPTORS OF CAROTID & AORTIC
BODIES W/RSLTG HYPERPNEA. CARD IR REGULARITY NOTED BUT HEART
INVARIABLY OUTLASTS RESPS. DEATH DUE TO RESP ARREST OF CENTRAL
ORIGIN; CAN (EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT
Effects of Overexposure:HLTH HAZ:OCCUR W/IN SEC/MIN OF HIGH CONC INHAL
OF HYDROGEN CYANIDE GAS. BECAUSE OF SLOWER ABSORPTION DEATH MAY BE
MORE DELAYED AFTER INGEST OF CYANIDE SALTS BUT CRITICAL EVENTS
STILL OCCUR W/IN FIRST HR. TWO OTHER SOURCES OF CYANIDE
RESPONSIBLE FOR HUMAN POIS. AMYGDALIN, A CYANOGENIC GLYCOSIDE FOUND
IN APRICOT,(SUPDAT)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

First Aid:SKIN: REMOVE CLTHG, RINSE SKIN W/SOAP & H*2O FOR CONSIDERABLE
TIME. PRDCES SEV CAUSTIC BURNS/GEN DISORDERS, TAKE TO HOSPITAL.
CALL MD. INGEST:RINSE MOUTH SEVERAL TIMES W/H*2O W/OUT SWALLOW.
DRINK 1-2 GLASSES OF WATER. IN CASE OF IMMINENT UNCON CLEAR RESP
TRACT, LAY ON SIDE IN STABLE POSITION. CALL MD/TAKE TO HOSPITAL.
EYES:RINSE W/H*2O FOR @ LST 15 MIN. CALL MD/TAKE TO HOSPITAL.
INHAL:GET (ING 25)

Flash Point:184F,84C
Extinguishing Media:CARBON DIOIXDE, DRY CHEMICAL, FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:MOD FIRE HAZ BY CHEM RXN W/HEAT,
MOISTURE, ACID. MANY CYANIDES EVOLVE HYDROCYANIC ACID RATHER
EASILY. THIS IS FLAM GAS & IS HIGHLY TOX. CO*2 FROM AIR IS(SUPDAT)

Spill Release Procedures:SWEEP INTO SUITABLE CONTAINER FOR DISPOSAL.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:STORE AT ROOM TEMPERATURE. ALWAYS WEAR
GLOVES, MASK, ANSI APPROVED GOGGLES AND USE A HOOD.
Other Precautions:DANGEROUS: ON CONTACT WITH ACID, ACID FUMES, WATER OR
STEAM, THEY WILL PRODUCE TOXIC AND FLAMMABLE VAPORS.

Respiratory Protection:USE NIOSH APPROVED RESPIRATOR APPROPRIATE FOR
EXPOSURE OF CONCERN .
Ventilation:LOCAL EXHAUST REQUIRED.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPRVD CHEM WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
Work Hygienic Practices:NONE SPECIFIED BY MANUFACTURER.
Supplemental Safety and Health
EXPLO HAZ:SUFFICIENTLY ACIDIC TO LIBERATE HYDROCYANIC ACID FROM CYANIDE
SOLNS. EXPLODES IF MELTED W/NITRATE OR CHLORATE @ ABOUT 450C.
VIOLENT RXN W/F*2, MG, NITRATES, HNO*3, NITRITES. EFTS OF OVEREXP:
PEACH & SIMILAR FRUIT PITS & IN SWEET ALMONDS. IT IS CHEM
COMBINATION OF GLUCOSE, BENZALDEHYDE & CYANIDE FROM (ING 2)

Boiling Pt:B.P. Text:394F,201C
Melt/Freeze Pt:M.P/F.P Text:>122F,>50C
Vapor Density:N//K
Solubility in Water:INSOLUBLE
Appearance and Odor:CHUNKY-WHITE CRYSTALS.

Stability Indicator/Materials to Avoid:NO
STRONG OXIDIZERS, STRONG ACIDS, STRONG BASES, STRONG REDUCING AGENTS.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:TOXIC FUMES OF CN, CARBON DIOXIDE,
NO*X, CARBON MONOXIDE.

Waste Disposal Methods:INCINERATE OR LANDFILL AS COMPLIES WITH FEDERAL,
STATE AND LOCAL LAWS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.